Stephen H Hughes Selected Research

Human immunodeficiency virus 1 p31 integrase protein

1/2018	Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants.
6/2014	4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1.
12/2012	6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.
2/2012	Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.
10/2011	Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572).

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Stephen H Hughes Research Topics

Disease

24	Infections 01/2023 - 12/2002
8	Neoplasms (Cancer) 04/2024 - 09/2006
6	HIV Infections (HIV Infection) 01/2023 - 12/2002
6	Acquired Immunodeficiency Syndrome (AIDS) 11/2021 - 12/2005
5	Viremia 01/2022 - 10/2011
3	COVID-19 02/2023 - 01/2021
2	Carcinogenesis 04/2024 - 05/2002
2	Virus Diseases (Viral Diseases) 02/2023 - 01/2023
2	Osteosarcoma (Osteogenic Sarcoma) 07/2008 - 09/2006
2	Avian Sarcoma 08/2005 - 08/2004
1	Papillomavirus Infections 04/2024
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 04/2024
1	Oropharyngeal Neoplasms 04/2024
1	T-Cell Lymphoma (Lymphoma, T Cell) 10/2021
1	Chromosomal Instability (Chromosome Stability) 07/2015
1	Drug-Related Side Effects and Adverse Reactions 01/2009
1	Lymphoma (Lymphomas) 05/2002
1	T-Cell Leukemia (Leukemia, T Cell) 03/2002

Drug/Important Bio-Agent (IBA)

8	DNA (Deoxyribonucleic Acid)IBA 04/2024 - 12/2006
7	IntegrasesIBA 11/2021 - 02/2014
6	NucleosidesIBA 12/2021 - 03/2005
5	Human immunodeficiency virus 1 p31 integrase proteinIBA 01/2018 - 10/2011
4	Reverse Transcriptase InhibitorsIBA 12/2021 - 03/2005
3	Viral DNAIBA 04/2024 - 01/2013
3	Viral RNAIBA 02/2023 - 01/2021
3	RNA (Ribonucleic Acid)IBA 01/2021 - 01/2019
3	Rilpivirine (TMC-278)IBA 01/2016 - 03/2005
2	Messenger RNA (mRNA)IBA 02/2023 - 01/2023
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 01/2022 - 12/2015
2	Zidovudine (Retrovir)FDA LinkGeneric 01/2022 - 12/2015
2	AntigensIBA 10/2021 - 01/2018
2	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 01/2021 - 12/2002
2	imidazole mustard (BIC)IBA 01/2020 - 05/2002
2	Anti-Retroviral Agents (Antiretroviral Agents)IBA 01/2016 - 02/2014
2	Raltegravir Potassium FDA Link 12/2012 - 10/2011
1	ChromatinIBA 01/2023
1	Lamivudine (Epivir)FDA Link 01/2022
1	abacavir (Ziagen)FDA Link 01/2022
1	dolutegravirIBA 12/2021
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 10/2021
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 10/2021
1	Phosphotransferases (Kinase)IBA 01/2021
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2018
1	EnzymesIBA 01/2016
1	histone H3 trimethyl Lys4IBA 07/2015
1	LuciferasesIBA 05/2014
1	Proteins (Proteins, Gene)FDA Link 01/2013
1	lens epithelium-derived growth factorIBA 01/2013
1	elvitegravirIBA 12/2012
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 04/2012
1	Cyclophilin AIBA 04/2012
1	Nevirapine (Viramune)FDA Link 04/2012
1	mRNA Cleavage and Polyadenylation FactorsIBA 03/2010
1	CarbasugarsIBA 09/2009
1	Ribonuclease H (RNase H)IBA 01/2009
1	Anti-HIV Agents (AIDS Drugs)IBA 01/2009
1	Adenosine Triphosphate (ATP)IBA 07/2008
1	VaccinesIBA 05/2008
1	Antiviral Agents (Antivirals)IBA 09/2006
1	(north)-methanocarbathymidineIBA 09/2006
1	Human immunodeficiency virus 1 reverse transcriptaseIBA 12/2005
1	CalciumIBA 08/2005
1	env Gene ProductsIBA 08/2005
1	Dantrolene (Dantrium)FDA LinkGeneric 08/2005
1	Glycoproteins (Glycoprotein)IBA 08/2004
1	Drug CombinationsIBA 12/2002
1	DNA Polymerase I (Klenow Fragment)IBA 12/2002
1	Untranslated RNA (Noncoding RNA)IBA 05/2002
1	SolutionsIBA 03/2002
1	OligonucleotidesIBA 03/2002
1	A-Form DNA (A-DNA)IBA 03/2002

Therapy/Procedure

5	Therapeutics 01/2022 - 12/2002
4	Highly Active Antiretroviral Therapy (HAART) 01/2023 - 02/2016
2	Art Therapy 10/2021 - 01/2021
1	Precision Medicine 04/2024